5-MTHF 5mg

by Thorne Research


Product Information

Folic acid must be converted to its active forms to be used by the body. This is a multi-step biochemical process that occurs in the intestines and liver. In the presence of intestinal or liver dysfunction this conversion may not occur sufficiently enough to meet the body's needs. Furthermore, up to 60-percent of the U.S. population may have a genetic enzyme defect that makes it difficult for them to convert folic acid into active 5-MTHF. For these individuals and many others, 5-MTHF supplementation may be a more effective method of folate repletion.

5-MTHF is an essential cofactor in the metabolism of the amino acid metabolite homocysteine. 5-MTHF also must be present in sufficient quantity for normal production of the neurotransmitters serotonin, melatonin, dopamine, epinephrine, and norepinephrine. These functions make 5-MTHF critical for both cardiovascular function and mood support.

  • a breakthrough in folate supplementation

  • the most bioavailable, active form of folate

  • an excellent source of folate for pregnant women*

  • supports optimal cardiovascular and nerve function*


One capsule contains: Folate (as L-5-Methyltetrahydrofolate) 5 mg.

Other ingredients: Microcrystalline Cellulose, Hypromellose (derived from cellulose) capsule, Leucine, Silicon Dioxide.

This product uses Gnosis S.p.A.'s L-5-Methyltetrahydrofolate (Extrafolate-S). Extrafolate-S is a registered trademark of Gnosis S.p.A.


Suggested use: Take 1 capsule two to three times daily or as recommended by a health-care practitioner.


The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide medical advice to individuals. Consult with your physician if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

60 capsules


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