by Thorne Research

Perfusia-SR is a sustained-release L-arginine - the most important cardiovascular product of the decade.

When sufficient L-arginine is present:

  • arteries relax, promoting optimal blood flow

  • as arteries relax, already normal blood pressure can be better maintained

  • erections occur in the normal course of intimacy

  • supple, flexible arteries are better able to support good cardiovascular health

Product Information
Sustained-release L-arginine supports cardiovascular function, wound healing, and immune function - and is a biological precursor to nitric oxide.

L-arginine is a semi-essential amino acid involved in multiple areas of human physiology and metabolism. L-arginine significantly affects endocrine function and helps regulate the release of neurotransmitter chemicals, insulin, glucagon (which has the opposite effect of insulin; i.e., it raises blood sugar), and growth hormone. However, one of L-arginine's most compelling contributions to human physiology is its role as a biological precursor of nitric oxide. The vascular endothelium (lining of the arteries) creates nitric oxide from L-arginine, resulting primarily in blood vessel relaxation.* This property is critical to maintaining good vascular health, heart health, reproductive health, and protection against oxidative damage.

Maintaining the natural, healthy functions of the vascular endothelium is dependent upon an adequate supply of L-arginine being available to these cells. As mentioned above, the conversion of L-arginine to nitric oxide is responsible for these functions by making the endothelial cells more resistant to oxidative damage and adhesion by otherwise harmful substances. Numerous studies have demonstrated that individuals with sufficient nitric oxide production by endothelial cells have the best opportunity to maintain already normal cardiovascular health.

In a large, double-blind trial that observed male reproductive health issues, 1.6 g L-arginine daily for six weeks resulted in improvement in reproductive health in those men with low nitric oxide metabolism.

Like most amino acids, L-arginine functions as a building block of proteins; however, its presence also appears to support wound healing. Numerous studies show L-arginine supplementation benefits wound healing time and strength of the tissue in and around the wound during the healing phase.

Without adequate L-arginine (and subsequently, nitric oxide) available to vascular endothelial cells, arteries may not optimally dilate, which can result in less than optimal blood flow to the organs and extremities.

L-arginine is absorbed and metabolized by the body very quickly, which usually necessitates taking it frequently throughout the day. Sustained-release Perfusia-SR, however, maintains an optimal level of L-arginine over 24 hours with suggested twice-daily use.

Studies on Perfusia-SR show increased blood flow to the heart muscle and the extremities, maintenance of already normal blood pressure, and improved vascular elasticity. A recent study demonstrated improvements in blood flow after Perfusia-SR supplementation in individuals with less than optimum heart health. In another study, Perfusia-SR was given to 29 healthy volunteers for one week and significant support of their already normal cardiovascular health was observed.

Two capsules contain: L-Arginine ( L-Arginine complexed with Time-Sorb, a patent-pending, time-release matrix) 1,000 mg.

Other ingredients: High and low viscosity hydroxypropyl methyl-cellulose and MagnesiumCitrateLaurate (Time-Sorb), Hypromellose (derived from cellulose) capsule, Leucine, Silicon Dioxide.

Suggested use: Take 2 capsules two times daily or as recommended by your health-care practitioner.

The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide medical advice to individuals. Consult with your physician if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

1,000 mg, 120 mg

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Dr. Ronald Hoffman

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product information by Thorne Research

L-Arginine in the Treatment of Pulmonary Hypertension Secondary to Pulmonary Embolism
Fukushima J Med Sci, 2010 Dec; 56(2): 135-8

L-Arginine plus Antioxidants Reduces the Risk of Pre-eclampsia
BMJ, 2011 May 19; [Epub ahead of print]

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